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When used as an adjunct to intensive behavioral therapy and initial low-calorie diet, once-weekly subcutaneous semaglutide produced significantly greater weight loss than placebo during 68 weeks in adults with overweight or obesity, according to a study published in JAMA. “We wanted to induce a...
By Denise Baez Altered evoked pain perception could potentially be used as a phenotypic biomarker of late-onset Alzheimer’s disease (AD) risk prior to disease onset, according to a study published in the Journal of Alzheimer’s Disease. The study showed that cognitively healthy apolipoprotein ɛ4 (...
Results from a large prospective study, published in Cancer, indicate that gastroesophageal reflux disease (GERD) is linked with higher risks of various cancers of the larynx and oesophagus. Christian C. Abnet, PhD, National Cancer Institute, part of the National Institutes of Health (NIH),...
White matter hyperintensities, which have been linked to Alzheimer’s disease, are found in patients with frontotemporal dementia, according to a study published in Neurology. “We were expecting to see similar amounts of white matter hyperintensities in frontotemporal dementia and Alzheimer’s...
The timing of moderate-to-vigorous physical activity (MVPA) is correlated to cardiorespiratory fitness and cardiovascular risk for men who have type 2 diabetes, according to research published in Diabetes Care. “The general message for our patient population remains that you should exercise...
The US Food and Drug Administration (FDA) has approved evinacumab-dgnb (Evkeeza) injection as an add-on treatment for patients aged 12 years and older with homozygous familial hypercholesterolemia (HoFH). The effectiveness and safety of evinacumab were evaluated in a double-blind, randomised,...
Immune responses to insulin could help identify individuals most at risk for developing type 1 diabetes, according to a study published in the Proceedings of the National Academy of Sciences. Aaron Michels, MD, Barbara Davis Center for Childhood Diabetes at the University of Colorado Anschutz...
New research published in The Journal of Alzheimer’s Disease Reports has found that being overweight is an additional burden on brain health and it may exacerbate Alzheimer’s disease. The pioneering multimodal neuroimaging study revealed obesity may contribute toward neural tissue vulnerability,...
A vaginal ring containing dapivirine and levonorgestrel delivered sustained levels of each drug when used continuously for 90 days -- levels likely sufficient to serve its dual purpose for protecting against both HIV and unwanted pregnancy, according to a study presented at the Virtual 4th HIV...
In a cohort study that included 28,024 women, diabetes and insulin resistance appeared to be the strongest risk factors for premature onset of coronary heart disease (CHD). The findings were published in JAMA Cardiology. “In this cohort study, associations of most risk factors with coronary heart...

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